[Effect of Cavinton on convulsions caused by chemical substances].

Abstract	Cavinton was shown to protect mice against convulsions induced by corazol, strychnine and thiosemicarbazide. In addition, cavinton exhibited a definite antagonism to convulsive reactions produced by systemic administration of penicillin to cats and a combined administration of penicillin (intramuscularly) with tryptophan metabolite, quinolinic acid (intracerebroventricularly). The anticonvulsant action of cavinton is suggested to be due to the involvement of the brain GABA- and serotonergic mechanisms. It is reasonable to test cavinton as a drug for treating some forms of epilepsy.
Authors	A A Dutov, B A Tolpyshev, V N Karpov, A P Petrov
Journal	Farmakologiia i toksikologiia (Farmakol Toksikol) 1986 Jul-Aug Vol. 49 Issue 4 Pg. 22-5 ISSN: 0014-8318 [Print] Russia (Federation)
Vernacular Title	Vliianie kavintona na sudorogi, vyzvannye khimicheskimi veshchestvami.
PMID	3758323 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References	Anticonvulsants Vinca Alkaloids vinpocetine
Topics	Animals Anticonvulsants (therapeutic use) Cats Drug Evaluation, Preclinical Electroencephalography Injections, Intraperitoneal Injections, Intraventricular Male Mice Seizures (chemically induced, drug therapy) Time Factors Vinca Alkaloids (therapeutic use)

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