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[Effect of antidepressants on the convulsive action of thiosemicarbazide, strychnine and corasol].

Abstract
Orally administered amitryptiline (25 and 50 mg/kg) protected animals against fatal convulsions induced by thiosemicarbazide, strychnine and metrazole. Vilaxazine had a protecting effect against death induced by strychnine. Impramine, maprotiline, mianserine and pirlindole (pyrazidol) only somewhat prolonged the latend period of convulsions and death, while incazane, caroxazone, nomifenzine and trazodone had practically no effect on the action of the three convulsants under study.
AuthorsS M Golovina, N I Andreeva
JournalBiulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 102 Issue 9 Pg. 290-2 (Sep 1986) ISSN: 0365-9615 [Print] Russia (Federation)
Vernacular TitleVliianie antidepressantov na sudorozhnoe deÄ­stvie tiosemikarbazida, strikhnina i korazola.
PMID3756328 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Anticonvulsants
  • Antidepressive Agents
  • Semicarbazides
  • thiosemicarbazide
  • Strychnine
  • Pentylenetetrazole
Topics
  • Animals
  • Anticonvulsants
  • Antidepressive Agents (pharmacology)
  • Female
  • Male
  • Mice
  • Pentylenetetrazole (antagonists & inhibitors)
  • Semicarbazides (antagonists & inhibitors)
  • Strychnine (antagonists & inhibitors)

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