Four groups of 10 horses (mares) each were treated with a 1%
solution of
ivermectin (200 micrograms/kg of
body weight) in a
propylene glycol-
glycerol formal base orally, a 1%
solution of
ivermectin (200 micrograms/kg) in a
propylene glycol-
glycerol formal base via nasogastric tube, a 1.87%
paste of
ivermectin (200 micrograms/kg) orally, or a 22.7%
paste of
oxibendazole (10 mg/kg) orally. Fecal examinations were done before treatment and on posttreatment days (PTD) 14, 28, 42, 56, and 70. Strongyle egg per gram counts and
sugar flotation fecal examinations were performed. Results of fecal examinations before treatment were similar in all horses. All horses treated with
ivermectin had similar percentages of reductions in mean strongyle egg per gram counts
after treatment; 100% on PTD 14, 28, and 56 and 93.4% to 98.7% on PTD 70. All
ivermectin treatment groups had 0 horses detected as passing strongyle eggs on PTD 14 and 28, 0 to 2 on PTD 42, 3 to 5 on PTD 56, and 8 to 9 on PTD 70. Horses treated with
oxibendazole had 99.9%, 99.7%, 92.9% 78.6%, and 54.5% reductions in mean strongyle egg per gram counts and 5, 7, 8, 9, and 9 horses detected as passing strongyle eggs on PTD 14, 28, 42, 56, and 70, respectively. Adverse reactions to treatment were not observed.