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Exercise and diet reduce muscle insulin resistance in obese Zucker rat.

Abstract
Two treatments that increase skeletal muscle insulin action are exercise training and high-carbohydrate diet. The purpose of the present study was to determine whether exercise training and a diet high in carbohydrates could function synergistically to reduce the muscle insulin resistance in the obese Zucker rat. Obese rats 4 wk of age were randomly assigned to an exercise or sedentary group. Each group was subdivided by diet with one-half of the rats fed a high-carbohydrate diet and one-half fed a high-fat diet. Lean Zucker rats fed the high-fat diet were used as controls. Muscle insulin resistance was assessed during hindlimb perfusion with a submaximally stimulating concentration of insulin. Exercise training and the high-carbohydrate diet increased the rate of muscle glucose uptake in the obese rat by 46 and 53%, respectively. More importantly, the combined effect of exercise training and high-carbohydrate diet was greater than the sum of their individual effects. Glycogen synthesis paralleled glucose uptake and was the major pathway for intracellular glucose disposal. Muscle glucose uptake for exercise-trained, high-carbohydrate fed obese rats was comparable with that of lean controls. It is concluded that exercise training and the high-carbohydrate diet functioned synergistically to reduce the muscle insulin resistance in the obese rat.
AuthorsJ L Ivy, W M Sherman, C L Cutler, A L Katz
JournalThe American journal of physiology (Am J Physiol) Vol. 251 Issue 3 Pt 1 Pg. E299-305 (Sep 1986) ISSN: 0002-9513 [Print] United States
PMID3752241 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Dietary Carbohydrates
  • Lactates
  • Lactic Acid
  • Glycogen
  • Hexokinase
  • Glucose
Topics
  • Animals
  • Dietary Carbohydrates (therapeutic use)
  • Glucose (metabolism)
  • Glycogen (biosynthesis)
  • Hexokinase (metabolism)
  • Insulin Resistance
  • Lactates (biosynthesis)
  • Lactic Acid
  • Muscles (metabolism)
  • Obesity (diet therapy, physiopathology, therapy)
  • Oxidation-Reduction
  • Physical Conditioning, Animal
  • Rats
  • Rats, Zucker

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