Efficacy of parvaquone and long-acting oxytetracycline in Theileria annulata infection.

Abstract

Therapeutic and prophylactic efficacies of parvaquone and long-acting oxytetracycline were tested against Theileria annulata infection, induced by injecting a suspension of infected ground tick tissues (GUTS) into groups of 4 or 5 calves. This infection killed two of four control calves, while all the animals given a single intramuscular dose of 20 mg kg-1 parvaquone or long-acting oxytetracycline on the day of infection underwent mild reactions and recovered. Two separate doses of parvaquone of 10 mg kg-1 administered on the first and second days of fever protected four out of five calves. All the recovered animals from both treated and control groups resisted a homologous challenge with GUTS on Day 45 post-infection which killed three out of four susceptible unimmunized control calves.

• Authors: G C Bansal, S P Sharma
• Journal: Veterinary parasitology (Vet Parasitol) Vol. 21 Issue 3 Pg. 145-9 (Aug 1986) ISSN: 0304-4017 [Print] Netherlands
• PMID: 3750805 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antiprotozoal Agents
• Naphthoquinones
• parvaquone
• Oxytetracycline

Topics

• Animals
• Antiprotozoal Agents (therapeutic use)
• Cattle
• Male
• Naphthoquinones (therapeutic use)
• Oxytetracycline (therapeutic use)
• Theileriasis (drug therapy)
• Ticks