Detrusor instability in children with recurrent urinary tract infection and/or enuresis. II. Treatment.

Abstract

Of 41 children, aged 5-15 years, referred consecutively because of recurrent urinary tract infections (UTIs) and/or enuresis, 18 (44%) showed detrusor instability (DI) in at least 2 of 6 CO2 cystometries. One child was excluded from the study because of lack of follow-up. Four children with less pronounced DI (instability during less than or equal to 50% of the cystometries performed) and frequent UTIs were given antibiotics prophylactically for 3 months. In the remaining 13 children, DI was found during more than half the cystometries performed, and 11 of these children, who also had urge incontinence, were treated with emepronium bromide, 400-600 mg daily (10-12 mg/kg) for 3 months. In 7 of the patients this treatment was supplemented by antibiotics prophylactically because of frequent UTIs. Two children with special problems received other types of treatment. All children were free from symptoms at a clinical check-up 6 months later, 95% confidence limits 0-20%.

• Authors: N Qvist, K K Nielsen, E S Kristensen, D Ehlers, K M Jensen, T Krarup, J Christoffersen
• Journal: Urologia internationalis (Urol Int) Vol. 41 Issue 3 Pg. 199-201 ( 1986) ISSN: 0042-1138 [Print] Switzerland
• PMID: 3750582 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Emepronium

Topics

• Adolescent
• Anti-Bacterial Agents (therapeutic use)
• Child
• Child, Preschool
• Cystoscopy
• Emepronium (therapeutic use)
• Enuresis (drug therapy, etiology, physiopathology)
• Female
• Humans
• Male
• Muscle, Smooth (physiopathology)
• Urinary Bladder (physiopathology)
• Urinary Bladder Diseases (complications, drug therapy)
• Urinary Tract Infections (drug therapy, etiology, physiopathology)
• Urodynamics