[Effect of chronic CCl4 poisoning in the rat and of partial hepatectomy of the pathologically altered organ on glycogen levels of hepatocytes].

A cytofluorometric study was made of total glycogen in rat liver cells in the norm and upon the chronic intoxication with CCl4. The liver cells were obtained from rats by means of intravital needle aspiration biopsy at the beginning of the experiment, after 3, and 6 months, and 1 month after partial hepatectomy of control and cirrhotic livers. Glycogen contents in liver cells were attributed to dry weight measured interferometrically. Upon the long-term chronic intoxication of rats with the hepatotropic poison the glycogen content increased by 1.4-2.5 times, and in some cells of cirrhotic livers even by 5-5.5 times compared to the normal level. 1 month after the resection both glycogen content and rat liver cell morphology were seen almost close to the normal. The data are discussed in terms of results earlier reported elsewhere on the increase of glycogen content in liver cells of patients with chronic hepatitis.
AuthorsM V Kudriavtseva, E E Zavadskaia, V A Ivanov, B N Kudriavtsev
JournalTsitologiia (Tsitologiia) Vol. 28 Issue 6 Pg. 607-14 (Jun 1986) ISSN: 0041-3771 [Print] USSR
Vernacular TitleVliianie khronicheskoń≠ intoksikatsii krys CCl4 i chastichnoń≠ gepatéktomii patologicheski izmenennogo organa na uroven' glikogena v gepatotsitakh.
PMID3750412 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Liver Glycogen
  • Animals
  • Biopsy, Needle
  • Carbon Tetrachloride Poisoning (metabolism, pathology)
  • Chronic Disease
  • Flow Cytometry
  • Hepatectomy
  • Liver (analysis, pathology)
  • Liver Glycogen (analysis)
  • Male
  • Microscopy, Interference
  • Rats
  • Time Factors

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