A comparison of the antithrombotic and haemorrhagic effects of a low molecular weight heparin (LHN-1) and conventional heparin.

Abstract

The antithrombotic effects after intravenous administration of a low molecular weight heparin (LHN-1) and conventional heparin were compared in a rabbit model of experimental thrombosis, where thrombus formation was induced by a combination of endothelial damage and stasis. Both compounds were able to prevent thrombosis completely. However, LHN-1 was significantly less potent than conventional heparin, the ratio between doses with the same antithrombotic effect being 2.4:1 on a weight basis. Bleeding times after administration of LHN-1 and conventional heparin were determined by tail transsection in anaesthetized rats and by template bleeding in the ear of conscious pigs. Given intravenously at a dose ratio of 2.4:1 (w/w), LHN-1 affected APTT less than conventional heparin, whereas the effects on haemostasis were not significantly different. In conclusion, it was found that after intravenous administration LHN-1 prevented experimental thrombosis as effectively as conventional heparin. However, the correlation between antithrombotic and haemorrhagic effects of LHN-1 was the same as that of conventional heparin. The corresponding relation in man remains to be determined.

• Authors: V Diness, J I Nielsen, P C Pedersen, K H Wolffbrandt, P B Ostergaard
• Journal: Thrombosis and haemostasis (Thromb Haemost) Vol. 55 Issue 3 Pg. 410-4 (Jun 30 1986) ISSN: 0340-6245 [Print] Germany
• PMID: 3750271 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Heparin

Topics

• Animals
• Bleeding Time
• Female
• Hemorrhage (chemically induced)
• Hemostasis (drug effects)
• Heparin (pharmacology)
• Male
• Partial Thromboplastin Time
• Rabbits
• Rats
• Rats, Inbred Strains
• Swine
• Thrombosis (drug therapy)