Drugs Halt Replication Later than Thought. -

Drugs Halt Replication Later than Thought.

Abstract	The use of CDK4/6 inhibitors, such as palbociclib, has shown promise in treating breast cancer. Data suggest these drugs reverse cell replication farther along in the cell cycle than previously thought-with expanded clinical benefits. Yet, more research is needed to prove that a CDK4/6 inhibitor plus chemotherapy provides irreversible cell senescence because unstable treated cells could replicate and increase risk of disease recurrence.
Authors
Journal	Cancer discovery (Cancer Discov) Vol. 13 Issue 9 Pg. 1955 (09 06 2023) ISSN: 2159-8290 [Electronic] United States
PMID	37489846 (Publication Type: News)
Copyright	©2023 American Association for Cancer Research.
Chemical References	Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 6 Protein Kinase Inhibitors
Topics	Humans Female Neoplasm Recurrence, Local Breast Neoplasms (drug therapy) Cell Line, Tumor Cell Cycle Cyclin-Dependent Kinase 4 (metabolism) Cyclin-Dependent Kinase 6 (metabolism) Protein Kinase Inhibitors (therapeutic use)

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