Derivatives of 2-N-arylalkylamino-2-methyl-1-propanol with antiarrhythmic activity.

Abstract	Several aryl derivatives of achiral 2-amino-2-methyl-1-propanol have been obtained and tested for prophylactic and curative activity in different types of experimental arrhythmia. Interesting results were obtained for compounds 3 and 4 with activity and toxicity similar to those of quinidine.
Authors	M Eckstein, J Zajaczkowska, J Krupińska, M Michna
Journal	Polish journal of pharmacology and pharmacy (Pol J Pharmacol Pharm) 1986 Mar-Apr Vol. 38 Issue 2 Pg. 215-20 ISSN: 0301-0244 [Print] Poland
PMID	3748893 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Arrhythmia Agents Propanolamines
Topics	Animals Anti-Arrhythmia Agents (chemical synthesis, toxicity) Arrhythmias, Cardiac (chemically induced, prevention & control) Guinea Pigs Male Mice Propanolamines (chemical synthesis, pharmacology, toxicity) Rats Rats, Inbred Strains

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