[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].

Abstract

Clove oil injection in the anterior chamber of the rabbit eye produces an uveitis and a disruption of the blood-ocular barrier which can be evaluated by the leakage of 125I-radiolabelled rabbit serum albumin (RSA) administered intravenously. In the normal rabbit eye the amount of RSA in the aqueous humor is quite small. The disruption of the blood-ocular barrier by clove oil injection increases the RSA level in the anterior chamber of the eye. Topically applied chromocarb diethylamine reduces significantly the disruption of the blood-ocular barrier in the inflamed eye. Despite of its lack of anti-inflammatory activity, this compound, as a 10% eye-drop formulation, was shown nearly as effective as prednisolone 0.1%, in the corneal edema and the disruption of the blood-ocular barrier.

• Authors: P Lapalus, V Bayer, F Lapalus
• Journal: Journal francais d'ophtalmologie (J Fr Ophtalmol) Vol. 9 Issue 2 Pg. 123-6 ( 1986) ISSN: 0181-5512 [Print] France
• Vernacular Title: Effets du chromocarbe diéthylamine et de la prednisolone sur l'uvéite expérimentale à l'essence de girofle chez le lapin.
• PMID: 3745792 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Chromones
• Diethylamines
• Drug Combinations
• Ophthalmic Solutions
• Eugenol
• Prednisolone
• chromocarb diethylamine

Topics

• Animals
• Chromones (administration & dosage, therapeutic use)
• Diethylamines (administration & dosage, therapeutic use)
• Disease Models, Animal
• Drug Combinations (administration & dosage, therapeutic use)
• Eugenol
• Male
• Ophthalmic Solutions
• Prednisolone (administration & dosage, therapeutic use)
• Rabbits
• Uveitis (chemically induced, drug therapy)