Tiapamil, a new calcium channel blocking agent for the treatment of effort induced chronic stable angina pectoris.

Abstract

The anti-anginal efficacy of tiapamil, a new calcium channel blocking agent was studied in 24 patients with established effort induced chronic stable angina pectoris. The patients were allocated randomly in a double-blind fashion to tiapamil 300 mg thrice daily or placebo for 2 weeks and thereafter all the patients received tiapamil 300 mg thrice daily in a single-blind fashion for a further 2 weeks. All patients performed symptom limited multistage graded exercise testing with computer-assisted analysis of the electrocardiogram before entering the study and at the end of the double-blind and single-blind phases. The mean exercise time to develop angina during the control test in the group which received placebo during the double-blind phase was 7.1 min; this increased to 8.5 min after 2 weeks of placebo and 9.7 min after 2 weeks of subsequent tiapamil therapy. Similarly in the group which received tiapamil during the double-blind phase the mean exercise time on control test was 6.4 min, increasing to 9.7 min and 9.7 min after 2 and 4 weeks of tiapamil therapy respectively. There were no statistical significant differences between the changes from control, seen with tiapamil and placebo during the double-blind phase. However, the changes observed between control and active therapy in the tiapamil group did reach statistical significance (p = 0.003). Similarly, 1 mm ST-segment depression time was prolonged by tiapamil therapy. The heart rate at rest and maximal exercise remained unaltered with tiapamil therapy.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: N S Khurmi, C W Robinson, M J O'Hara, E B Raftery
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 30 Issue 4 Pg. 387-92 ( 1986) ISSN: 0031-6970 [Print] Germany
• PMID: 3743614 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Calcium Channel Blockers
• Propylamines
• Tiapamil Hydrochloride

Topics

• Adult
• Aged
• Angina Pectoris (drug therapy)
• Calcium Channel Blockers (adverse effects, therapeutic use)
• Chronic Disease
• Double-Blind Method
• Electrocardiography
• Exercise Test
• Female
• Hemodynamics (drug effects)
• Humans
• Male
• Middle Aged
• Propylamines (adverse effects, therapeutic use)
• Random Allocation
• Tiapamil Hydrochloride