Abstract |
We evaluated the efficacy of N-Acetyl-Aspartyl-Glutamic acid ( magnesium salt) ( NAAGA) eye-drops in preventing the conjunctival and uveal allergic inflammation induced by reverse passive Arthus reaction in the rabbit. The permeability of the blood-conjunctival and blood-aqueous barriers was investigated by the leakage of 125I-labelled rabbit serum albumin injected intravenously prior to the challenge with the antigen. Permeability of both barriers was markedly increased 2 hours after the triggering of the allergic reaction; marked edema of the conjunctiva was also observed. Pretreatment with 1, 3, 6% (w/w) NAAGA eye-drops prevented the conjunctival inflammatory changes in a dose related manner and to a lesser degree, the breakdown of the blood-aqueous barrier. The distribution of topically applied 14C-NAAGA in the rabbit eyes was also investigated.
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Authors | P Lapalus, G Moulin, V Bayer, D Fredj-Reygrobellet, P P Elena |
Journal | Current eye research
(Curr Eye Res)
Vol. 5
Issue 7
Pg. 517-22
(Jul 1986)
ISSN: 0271-3683 [Print] England |
PMID | 3743112
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dipeptides
- Serum Albumin
- isospaglumic acid
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Topics |
- Animals
- Aqueous Humor
(metabolism)
- Capillary Permeability
- Conjunctivitis
(drug therapy, metabolism)
- Dipeptides
(therapeutic use)
- Eye
(metabolism)
- Hypersensitivity
(drug therapy, metabolism)
- Kinetics
- Osmolar Concentration
- Rabbits
- Serum Albumin
(metabolism)
- Time Factors
- Uveitis
(drug therapy, metabolism)
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