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Effects of a new anti-allergic agent: the magnesium salt of N-acetyl-aspartyl-glutamic acid on experimental allergic inflammation of the rabbit eye.

Abstract
We evaluated the efficacy of N-Acetyl-Aspartyl-Glutamic acid (magnesium salt) (NAAGA) eye-drops in preventing the conjunctival and uveal allergic inflammation induced by reverse passive Arthus reaction in the rabbit. The permeability of the blood-conjunctival and blood-aqueous barriers was investigated by the leakage of 125I-labelled rabbit serum albumin injected intravenously prior to the challenge with the antigen. Permeability of both barriers was markedly increased 2 hours after the triggering of the allergic reaction; marked edema of the conjunctiva was also observed. Pretreatment with 1, 3, 6% (w/w) NAAGA eye-drops prevented the conjunctival inflammatory changes in a dose related manner and to a lesser degree, the breakdown of the blood-aqueous barrier. The distribution of topically applied 14C-NAAGA in the rabbit eyes was also investigated.
AuthorsP Lapalus, G Moulin, V Bayer, D Fredj-Reygrobellet, P P Elena
JournalCurrent eye research (Curr Eye Res) Vol. 5 Issue 7 Pg. 517-22 (Jul 1986) ISSN: 0271-3683 [Print] England
PMID3743112 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Dipeptides
  • Serum Albumin
  • isospaglumic acid
Topics
  • Animals
  • Aqueous Humor (metabolism)
  • Capillary Permeability
  • Conjunctivitis (drug therapy, metabolism)
  • Dipeptides (therapeutic use)
  • Eye (metabolism)
  • Hypersensitivity (drug therapy, metabolism)
  • Kinetics
  • Osmolar Concentration
  • Rabbits
  • Serum Albumin (metabolism)
  • Time Factors
  • Uveitis (drug therapy, metabolism)

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