Infection of CBA/J mice with 250 ova of Toxocara canis results in development of splenic lymphocytes hyperergic to nonspecific stimuli. These studies were performed to see if the granulomatous response to a nonspecific stimulus was exaggerated. Using eosinophil counts and
MBSA ear thickening it was demonstrated that concurrent
infection with the parasite and immunization with
methylated bovine serum albumin (
MBSA) elicit no immunologic cross reactions. Eosinophil counts were proportional to the worm burden and unaffected by concurrent
MBSA immunization. Embolization of
Sepharose 4B beads conjugated to
MBSA into the pulmonary vasculature of
MBSA-immune mice, elicited large, florid macrophage-rich granulomata while in
MBSA-naive mice infected with 10 T. canis ova, the beads elicited small,
foreign body reactions. In
MBSA-naive mice infected with 250 T. canis ova
MBSA-coated beads elicited eosinophil-rich granulomata that were as large or larger than the granulomata in
MBSA-immune mice. In mice immune and infected, lesions contained eosinophils in proportion to larval worm burdens. Because
MBSA beads elicited large, eosinophilic granulomata in T. canis infected,
MBSA-naive mice it is concluded that the lung is hyperergic and the disease process appears similar to other kinds of eosinophilic
pneumonitis such as
bronchial asthma or Loeffler's
pneumonia.