[Electrophysiological action of ethacizin in acute myocardial ischemia in dogs].

Abstract

The effects of ethacizin on delayed activation of the ischemic myocardium by acute left anterior descending coronary artery occlusion were studied in dogs. Ethacizin, administered intravenously at a dose of 0.5 or 1 mg/kg depressed the conduction of excitation in the ischemic myocardium and significantly increased the incidence of ventricular fibrillation. Electrophysiological effects of ethacizin in acute myocardial ischemia, as well as its antiarrhythmic activity at the advanced stages of experimental myocardial infarction might be related to an intensive influence of ethacizin on fast inward sodium current in the myocardial fibers.

• Authors: E P Aniukhovskiĭ, L V Rozenshtraukh, G G Beloshapko, A V Iushmanova, N V Shestakova
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 102 Issue 8 Pg. 189-92 (Aug 1986) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Elektrofiziologicheskoe deĭstvie étatsizina pri ostroĭ ishemii miokarda u sobak.
• PMID: 3742033 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Phenothiazines
• diethylamino-ethmozine
• Moricizine

Topics

• Animals
• Anti-Arrhythmia Agents (pharmacology)
• Coronary Disease (drug therapy, physiopathology)
• Dogs
• Electrocardiography
• Heart (drug effects, physiopathology)
• Moricizine (analogs & derivatives)
• Phenothiazines (pharmacology)