Zebrafish optomotor response to second-order motion illustrates that age-related changes in motion detection depend on the activated motion system.

Abstract

Various aspects of visual functioning, including motion perception, change with age. Yet, there is a lack of comprehensive understanding of age-related alterations at different stages of motion processing and in each motion system. To understand the effects of aging on second-order motion processing, we investigated optomotor responses (OMR) in younger and older wild-type (AB-strain) and acetylcholinesterase (achesb55/+) mutant zebrafish. The mutant fish with decreased levels of acetylcholinesterase have been shown to have delayed age-related cognitive decline. Compared to previous results on first-order motion, we found distinct changes in OMR to second-order motion. The polarity of OMR was dependent on age, such that second-order stimulation led to mainly negative OMR in the younger group while older zebrafish had positive responses. Hence, these findings revealed an overall aging effect on the detection of second-order motion. Moreover, neither the genotype of zebrafish nor the spatial frequency of motion significantly changed the response magnitude. Our findings support the view that age-related changes in motion detection depend on the activated motion system.

• Authors: Aysenur Karaduman, Elif Tugce Karoglu-Eravsar, Utku Kaya, Alaz Aydin, Michelle M Adams, Hulusi Kafaligonul
• Journal: Neurobiology of aging (Neurobiol Aging) Vol. 130 Pg. 12-21 (Oct 2023) ISSN: 1558-1497 [Electronic] United States
• PMID: 37419077 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 Elsevier Inc. All rights reserved.