HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Systemic antibiotic prophylaxis with metronidazole in elective colonic and rectal surgery. Results of a clinical controlled study and a critical literature review].

Abstract
The pathogen spectrum of wound infections in colon surgery is composed almost exclusively of facultatively aerobic and obligatorily anaerobic intestinal flora. A study was performed in which a one-shot prophylaxis was carried out by applying metronidazole, 500 mg i.v., or latamoxef (lamoxactam) 2 g i.v., on induction of anesthesia. The metronidazole group evidenced a 26.3% incidence of infections due exclusively to aerobic pathogens. In the latamoxef (lamoxactam) group, it was possible to achieve a reduction of the postoperative rate of wound infections to 11.1%. The study was prematurely terminated because of the high rate of wound infections in the metronidazole group and the exclusive selecting of aerobic pathogens.
AuthorsG Raetzel, B M Harnoss, G Görtz, R Häring, A Rodloff
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 36 Issue 6 Pg. 976-80 (Jun 1986) ISSN: 0004-4172 [Print] Germany
Vernacular TitleSystemische Antibiotikaprophylaxe mit Metronidazol in der elektiven Kolon- und Rektumchirurgie. Ergebnisse einer klinisch-kontrollierten Studie und kritische Literaturübersicht.
PMID3741534 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Metronidazole
Topics
  • Colon (surgery)
  • Humans
  • Metronidazole (therapeutic use)
  • Premedication
  • Rectum (surgery)
  • Surgical Wound Infection (microbiology, prevention & control)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: