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Kinetics of 2,4,6-trichlorophenol in different organs of the rat.

Abstract
The concentration of 2,4,6-trichlorophenol was measured in the blood and various other tissues of the rat after IP administration of the compound at 25 mg per kg body weight. The highest concentration, 329 +/- 117 nmol X g-1, was found in the kidney. Half-times were between 1.4 and 1.8 h in the blood, brain, fat, kidney, liver and muscle. The extent of conjugation of 2,4,6-trichlorophenol was also investigated by measuring total and free chlorophenol in the blood.
AuthorsK Pekari, C Boudène, A Aitio
JournalArchives of toxicology (Arch Toxicol) Vol. 59 Issue 1 Pg. 41-4 (May 1986) ISSN: 0340-5761 [Print] Germany
PMID3741142 (Publication Type: Journal Article)
Chemical References
  • Chlorophenols
  • Glucuronates
  • 2,4,6-trichlorophenol
Topics
  • Animals
  • Chlorophenols (blood, metabolism)
  • Chromatography, Gas
  • Female
  • Glucuronates (metabolism)
  • Kinetics
  • Organ Size
  • Organ Specificity
  • Rats
  • Rats, Inbred Strains
  • Tissue Distribution

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