[Efficacy of a latex Foley catheter with sustained release of chlorhexidine: 1st report: Clinical trials for the prevention of urinary tract infection].

Abstract

Seventy five patients requiring urethral catheterization for over 24 hours were treated with a latex Foley catheter with sustained release of chlorhexidine in a closed drainage system. While the catheter was indwelling, urinary concentrations of chlorhexidine were maintained at the level of 1 to 2 micrograms/ml in average in almost all patients. The catheter was highly effective in preventing the acquisition of catheter-associated bacteriuria in patients with initially sterile urine without systemic antimicrobial therapy. The acquisition rate of bacteriuria was 8, 16, 23, 35 and 74% on day 3, 4, 5, 6 and 7 with the catheter indwelling, respectively. The catheter was not effective in eradicating preexisting bacteriuria. Complications of the catheter were minimal.

• Authors: H Nakano, S Seko, T Sumii, H Nihira, M Fujii, K Okada, T Kitano, M Kodama, Y Ohnishi, T Okutani
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 32 Issue 4 Pg. 567-74 (Apr 1986) ISSN: 0018-1994 [Print] Japan
• PMID: 3739862 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Infective Agents, Urinary
• Chlorhexidine

Topics

• Adult
• Aged
• Anti-Infective Agents, Urinary (administration & dosage)
• Bacteriuria (etiology, prevention & control)
• Catheters, Indwelling
• Chlorhexidine (administration & dosage)
• Female
• Humans
• Male
• Middle Aged
• Urethra
• Urinary Catheterization (adverse effects, instrumentation)