Intradermal Delivery of Alopecia Therapeutics: Current State and Future Prospects.

Abstract

BACKGROUND:

Mesotherapy, a technique of transdermal microinjections of specific preparations, is increasingly used in fields such as dermatology and specifically for alopecia treatment. Its popularity stems from its ability to deliver drugs in a targeted manner while minimizing systemic side effects.

OBJECTIVE:

To assess and review current knowledge regarding the use of mesotherapy to deliver alopecia medications and highlight future directions for research.

MATERIALS AND METHODS:

The authors used research databases including PubMed and Google Scholar to identify current literature on mesotherapy and alopecia. The following search terms were used among other terms: "Mesotherapy" or "Intradermal" AND "Alopecia".

RESULTS:

Recent studies are promising for the intradermal delivery of dutasteride and minoxidil in the treatment of androgenetic alopecia.

CONCLUSION:

Although limitations exist with dutasteride and minoxidil therapies, further research regarding the preparation, delivery, and maintenance of these drugs is warranted as mesotherapy could establish this technique as a safe, effective, and viable treatment option for androgenetic alopecia.

• Authors: Lina Alhanshali, Michael Buontempo, Daniela Majerson, Jerry Shapiro, Kristen Lo Sicco
• Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (Dermatol Surg) Vol. 49 Issue 9 Pg. 851-854 (09 01 2023) ISSN: 1524-4725 [Electronic] United States
• PMID: 37387642 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Dutasteride
• Minoxidil

Topics

• Humans
• Dutasteride (therapeutic use)
• Minoxidil (therapeutic use)
• Alopecia (drug therapy)
• Mesotherapy
• Drug-Related Side Effects and Adverse Reactions
• Treatment Outcome