Relationship between serum concentration and daily dose of dantrolene in cerebral palsy patients.

Abstract

Serum concentration of dantrolene and its active metabolite, 5-hydroxydantrolene were determined in 27 cerebral palsy patients. Correlation coefficients between the oral dose of dantrolene and serum levels of dantrolene and its major metabolite, 5-hydroxydantrolene were rather small in cerebral palsy patients. The mean half-times of dantrolene and 5-hydroxydantrolene were 3.41 (n = 6) and 4.00 (n = 5) hours, respectively. These values were about a half of those reported earlier [Lietman et al., 1974; Meyler et al., 1979; Flewellen et al., 1983]. The poor correlation between serum level and dose may be due to the variation in an extent of oral dantrolene availability.

• Authors: N Inotsume, A Higashi, I Matsukane, S Chikazawa, M Nakano, I Matsuda
• Journal: Pediatric pharmacology (New York, N.Y.) (Pediatr Pharmacol (New York)) Vol. 5 Issue 4 Pg. 253-9 ( 1986) ISSN: 0270-322X [Print] United States
• PMID: 3737270 (Publication Type: Journal Article)

Chemical References

• 5-hydroxydantrolene
• Dantrolene

Topics

• Adolescent
• Adult
• Cerebral Palsy (blood, drug therapy)
• Child
• Child, Preschool
• Dantrolene (administration & dosage, analogs & derivatives, metabolism)
• Dose-Response Relationship, Drug
• Female
• Humans
• Kinetics
• Male
• Metabolic Clearance Rate