Effects of trimeprazine and trimipramine on nocturnal scratching in patients with atopic eczema.

Abstract

Twelve men with severe and long-standing atopic eczema were admitted to a double-blind trial to establish the effects of trimeprazine tartrate, trimipramine maleate, and placebo on nocturnal scratching. Neither of the drugs altered the likelihood of a scratching bout beginning in wakefulness or in any stage of sleep. However, both drugs, especially trimipramine, made sleep less broken, and the reduced time spent in stage 1 of sleep accounted for a modest reduction in the overall amount of scratching during the night.

• Authors: J A Savin, W D Paterson, K Adam, I Oswald
• Journal: Archives of dermatology (Arch Dermatol) Vol. 115 Issue 3 Pg. 313-5 (Mar 1979) ISSN: 0003-987X [Print] United States
• PMID: 373632 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Dibenzazepines
• Placebos
• Trimipramine
• Trimeprazine

Topics

• Adult
• Clinical Trials as Topic
• Dibenzazepines (therapeutic use)
• Double-Blind Method
• Eczema (complications)
• Humans
• Male
• Placebos
• Pruritus (drug therapy, etiology)
• Sleep Stages (drug effects)
• Trimeprazine (pharmacology, therapeutic use)
• Trimipramine (pharmacology, therapeutic use)