Alterations in calcium, phosphorus and C-terminal parathyroid hormone levels in equine acute renal disease.

Abstract

The changes in serum and urinary levels of calcium and phosphorus and serum parathyroid hormone (PTH) were studied during controlled, chemically induced, acute renal disease in 4 ponies. There was an initial rise in daily urinary calcium and hydroxyproline excretion in 2 ponies which may have indicated increased bone resorption. Mild hypercalcemia, hypophosphatemia and elevated C-terminal PTH levels were associated with oliguria. Total daily urinary excretion of calcium and phosphorus decreased as oliguria developed. The levels of C-terminal PTH were increased in all four animals. This appears to have been related to their diminished renal function in that C-terminal fragments of intact PTH (which require functioning kidneys in order to be cleared) were probably being accumulated. Although there was no evidence with regard to an actual increase in PTH secretion, prolongation of intact PTH half-life due to renal tubular damage may have contributed to the development of hypercalcemia.

• Authors: R S Elfers, W M Bayly, D F Brobst, S M Reed, H D Liggitt, C D Hawker, D J Baylink
• Journal: The Cornell veterinarian (Cornell Vet) Vol. 76 Issue 3 Pg. 317-29 (Jul 1986) ISSN: 0010-8901 [Print] United States
• PMID: 3731786 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Chromates
• Parathyroid Hormone
• Peptide Fragments
• Phosphates
• carboxyl-terminal parathyroid hormone
• Mercuric Chloride
• sodium bichromate
• Hydroxyproline
• Calcium

Topics

• Acute Kidney Injury (blood, chemically induced, urine)
• Animals
• Calcium (blood, urine)
• Chromates
• Horses
• Hydroxyproline (urine)
• Male
• Mercuric Chloride
• Orchiectomy
• Parathyroid Hormone (blood, urine)
• Peptide Fragments (blood, urine)
• Phosphates (blood, urine)