Prophylaxis with cefamandole nafate in elective orthopedic surgery.

Abstract

A prospective, randomized, double-blind study was conducted to determine the efficacy of cefamandole nafate in reducing infections in general orthopedic procedures. Of 743 patients initially entered into the study, 715 (362 on cefamandole, 353 on placebo) fulfilled the requirements of the protocol. The infection rate was 1.6% for the cefamandole-treated group and 4.2% for the placebo group. In operations lasting longer than two hours, there were two infections in the cefamandole group and seven infections in the placebo group (p less than 0.05). Staphylococcus aureus and gram-negative bacilli were the common pathogens. Adverse side effects were limited to transient elevations in liver enzymes.

• Authors: M B Henley, R E Jones, R W Wyatt, A Hofmann, R L Cohen
• Journal: Clinical orthopaedics and related research (Clin Orthop Relat Res) Issue 209 Pg. 249-54 (Aug 1986) ISSN: 0009-921X [Print] United States
• PMID: 3731606 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Placebos
• Cefamandole
• cefamandole nafate

Topics

• Adult
• Bacterial Infections (prevention & control)
• Cefamandole (analogs & derivatives, therapeutic use)
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Placebos
• Prospective Studies
• Random Allocation
• Surgical Wound Infection (prevention & control)