HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Is succinyldicholine the substrate of choice for the measurement of cholinesterase activity?

Abstract
We have developed a succinyldicholine-based assay for serum cholinesterase (EC 3.1.1.8) to help establish whether patients with suspected sensitivity to drugs of this type have enzyme abnormalities that cannot be detected by conventional laboratory techniques. Although the method discriminates between cholinesterase activities of drug-sensitive and nonsensitive people as well as an assay involving propionylthiocholine does, it has not revealed cholinesterase abnormalities in patients who experienced prolonged apnea after succinyldicholine, in whom no enzyme defect could be demonstrated by other procedures. Of 50 individuals who were apneic for between 20 and 180 min, only one had a cholinesterase activity less than the mean for E1u homozygotes by more than 2.5 SD. We conclude that the number of patients who experience clinical problems due to enzyme abnormalities that at present go unrecognized is small. Consequently, although succinyldicholine might eventually become the substrate of choice for cholinesterase, its advantages over propionylthiocholine are not yet sufficient to encourage its use.
AuthorsS Faye, R T Evans
JournalClinical chemistry (Clin Chem) Vol. 32 Issue 8 Pg. 1477-80 (Aug 1986) ISSN: 0009-9147 [Print] England
PMID3731440 (Publication Type: Journal Article)
Chemical References
  • propionylthiocholine
  • Thiocholine
  • Cholinesterases
  • Succinylcholine
Topics
  • Adult
  • Apnea (enzymology)
  • Cholinesterases (analysis)
  • Heterozygote
  • Humans
  • Male
  • Middle Aged
  • Succinylcholine (metabolism)
  • Thiocholine (analogs & derivatives)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: