An artificial viral capsid decorated with a DNA aptamer internalizing into lymphoma cells.

Abstract

Tumor-specific drug-delivering nanocarriers could be a promising modality for next-generation tumor therapy. Here we developed a Burkitt lymphoma-specific DNA aptamer-labeled nanocarrier using the β-Annulus peptide, which forms a spherical nanoassembly called artificial viral capsid. Dynamic light scattering and transmission electron microscopy of the DNA aptamer-decorated artificial viral capsid showed the formation of spherical assemblies with a diameter of approximately 50-150 nm. The artificial viral capsid was selectively internalized into the Burkitt lymphoma cell line, Daudi, and doxorubicin complexed with the capsid selectively killed Daudi cells.

• Authors: Kentarou Sakamoto, Kohsuke Uchiyama, Takashi Iwasaki, Hiroshi Inaba, Kazunori Matsuura
• Journal: Journal of materials chemistry. B (J Mater Chem B) Vol. 11 Issue 26 Pg. 6053-6059 (07 05 2023) ISSN: 2050-7518 [Electronic] England
• PMID: 37310262 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aptamers, Nucleotide
• Peptides
• Doxorubicin

Topics

• Humans
• Aptamers, Nucleotide
• Capsid
• Burkitt Lymphoma (drug therapy)
• Peptides
• Doxorubicin (pharmacology)