Effect of the alpha-glucosidase inhibitor Bay-O-1248 on the metabolic response of nondiabetic and diabetic rats to a high-carbohydrate diet.

Abstract

The metabolic consequences of the addition of a new alpha-glucosidase inhibitor (BAY-O-1248) to a high carbohydrate diet (67% by calories) in which the carbohydrate comprised equal quantities (50% wt/wt) of wheat starch and sucrose (Diet A) or 100% glucose (Diet B) was studied in diabetic and nondiabetic rats. BAY-O-1248 led to a significant reduction in daily food intake and weight gain in rats fed Diet A but not Diet B. In diabetic rats fed Diet A with BAY-O-1248, daily urinary glucose was significantly diminished (6820 +/- 402 vs 3796 +/- 210 mg), while the postprandial plasma glucose excursions were similar. In nondiabetic rats, the addition of BAY-O-1248 decreased the postprandial plasma glucose level with no change in urine glucose. In summary, addition of an alpha-glucosidase inhibitor to a starch plus sucrose containing diet led to reductions in glycosuria (diabetic rats) and serum glucose levels (normal rats).

• Authors: Z Madar, J Olefsky
• Journal: The American journal of clinical nutrition (Am J Clin Nutr) Vol. 44 Issue 2 Pg. 206-11 (Aug 1986) ISSN: 0002-9165 [Print] United States
• PMID: 3728357 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Blood Glucose
• Dietary Carbohydrates
• Triglycerides
• 1-Deoxynojirimycin
• Cholesterol
• Glucosamine
• emiglitate

Topics

• 1-Deoxynojirimycin (analogs & derivatives)
• Animals
• Blood Glucose
• Body Weight (drug effects)
• Cholesterol (blood)
• Diabetes Mellitus, Experimental (metabolism)
• Dietary Carbohydrates (metabolism)
• Glucosamine (analogs & derivatives, toxicity)
• Glycosuria (chemically induced, metabolism)
• Male
• Rats
• Rats, Inbred Strains
• Triglycerides (blood)