[Stem Cell Therapy for Complex Anal Fistula in Crohn`s Disease: Current Evidence and Future Perspectives].

Abstract

Despite progress in multidisciplinary diagnostic and therapeutic strategies, complex anal fistulas associated with Crohn's disease remain a challenge for both medical and surgical management. Conventional surgical techniques such as flap procedures or LIFT are still associated with considerable persistence and recurrence rates. Based on this background, results of stem cell therapy for Crohn's anal fistula have shown promising results and are a sphincter-preserving technique. In particular, adipose-derived, allogeneic stem cell therapy (Darvadstrocel) has shown encouraging healing rates within the randomised controlled ADMIRE-CD trial, which were reproducible in "real world" data of limited clinical studies. The current evidence has led to the integration of allogeneic stem cell therapy into international guidelines. To date, the definitive status of allogeneic stem cells in the multidisciplinary treatment algorithm for complex anal fistulas associated with Crohn's disease cannot be evaluated.

• Authors: Oliver Schwandner
• Journal: Zentralblatt fur Chirurgie (Zentralbl Chir) Vol. 148 Issue 3 Pg. 220-227 (Jun 2023) ISSN: 1438-9592 [Electronic] Germany
• Vernacular Title: Stammzelltherapie bei komplexen perianalen Fisteln bei Morbus Crohn: Aktuelle Evidenz und Ausblick.
• PMID: 37267976 (Publication Type: English Abstract, Journal Article)
• Copyright: Thieme. All rights reserved.

Topics

• Humans
• Treatment Outcome
• Crohn Disease (therapy, surgery)
• Wound Healing
• Rectal Fistula (etiology, surgery)
• Cell- and Tissue-Based Therapy