Facilitation of olfactory bulb kindling after specific destruction of serotoninergic terminals in the olfactory bulb of the rat.

Abstract

The role of serotonin (5-HT) in the kindling model of epilepsy was investigated by performing specific lesions of the 5-HT innervation at the level of the primary epileptogenic focus. We injected bilaterally 5,6-dihydroxytryptamine in the olfactory bulb (OB) of adult rats which were submitted to electrical stimulations of the OB until the occurrence of stage-5 seizures. Immunohistochemical controls of lesions were realized with a specific anti-5-HT antibody. Results revealed that the lesions facilitated the initial development of kindling (increase of afterdischarge duration and of kindling rate), suggesting that 5-HT terminals exert a modulatory effect on the propagation of the epileptic activity.

• Authors: M Lerner-Natoli, G Rondouin, A Malafosse, F Sandillon, A Privat, M Baldy-Moulinier
• Journal: Neuroscience letters (Neurosci Lett) Vol. 66 Issue 3 Pg. 299-304 (May 23 1986) ISSN: 0304-3940 [Print] Ireland
• PMID: 3725194 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hydroxydopamines
• Serotonin

Topics

• Animals
• Electric Stimulation
• Electroshock
• Hydroxydopamines (pharmacology)
• Kindling, Neurologic (drug effects)
• Male
• Nerve Degeneration
• Nerve Endings (drug effects, physiology)
• Olfactory Bulb (drug effects, physiology)
• Rats
• Seizures (physiopathology)
• Serotonin (physiology)