Celiac disease presenting as chronic hepatitis in a girl.

Abstract

A case of celiac disease presenting as an asymptomatic chronic persistent hepatitis in an 11-year-old girl is reported. Liver biopsy performed because of long-standing elevation of serum transaminase levels showed a mild portal fibrosis with mononuclear infiltrate. Immunofluorescence staining did not reveal deposits of immunoglobulins or complement in the liver specimen. Although the girl was totally asymptomatic, she had steatorrhea, a delayed bone age, and an abnormal D-xylose test. A jejunal biopsy showed villous atrophy and increased intraepithelial lymphocytes. On a gluten-free diet the level of transaminases fell to normal within 1 month and remained normal. According to biological remission, a second intestinal biopsy performed after 1 year of gluten-free diet revealed a normal intestinal mucosa. Our report suggests that an underlying chronic intestinal disorder, and particularly celiac disease, must be ruled out when evaluating a child with elevated levels of serum transaminase.

• Authors: G Maggiore, C De Giacomo, M S Scotta, F Sessa
• Journal: Journal of pediatric gastroenterology and nutrition (J Pediatr Gastroenterol Nutr) 1986 May-Jun Vol. 5 Issue 3 Pg. 501-3 ISSN: 0277-2116 [Print] United States
• PMID: 3723275 (Publication Type: Case Reports, Journal Article)

Topics

• Celiac Disease (diagnosis)
• Child
• Chronic Disease
• Diagnosis, Differential
• Female
• Hepatitis (diagnosis)
• Humans