Opioid peptides derived from food proteins. The exorphins.

Abstract

Peptides with opioid activity are found in pepsin hydrolysates of wheat gluten and alpha-casein. The opioid activity of these peptides was demonstrated by use of the following bioassays: 1) naloxone-reversible inhibition of adenylate cyclase in homogenates of neuroblastoma X-glioma hybrid cells; 2) naloxone-reversible inhibition of electrically stimulated contractions of the mouse vas deferens; 3) displacement of [3H]dihydromorphine and [3H-Tyr, dAla2]met-enkephalin amide from rat brain membranes. Substances which stimulate adenylate cyclase and increase the contractions of the mouse vas deferens but do not bind to opiate receptors are also isolated from gluten hydrolysates. It is suggested that peptides derived from some food proteins may be of physiological importance.

• Authors: C Zioudrou, R A Streaty, W A Klee
• Journal: The Journal of biological chemistry (J Biol Chem) Vol. 254 Issue 7 Pg. 2446-9 (Apr 10 1979) ISSN: 0021-9258 [Print] United States
• PMID: 372181 (Publication Type: Journal Article)

Chemical References

• Caseins
• Dietary Proteins
• Narcotics
• Peptides
• exorphins
• Glutens
• Pepsin A
• Adenylyl Cyclases

Topics

• Adenylyl Cyclases (metabolism)
• Animals
• Biological Assay
• Caseins
• Dietary Proteins
• Glutens
• Kinetics
• Male
• Narcotics (pharmacology)
• Pepsin A
• Peptides (pharmacology)