Use of alpha-tocopherylquinone in the treatment of ulcerative colitis.

Abstract

The effect of alpha-tocopherylquinone (alpha-TQ) and a low fat diet on a patient with chronic continuous ulcerative colitis was described. The patient's condition improved dramatically with both colonic and extraintestinal manifestations of the disease greatly reduced with doses of alpha-TQ of 3.0 g/day (50 mg/kg/d) or greater. Withdrawal of alpha-TQ for periods of one to two days produced recurrence of inflammation which was again reduced upon re-introduction of alpha-TQ.

• Authors: J D Bennet
• Journal: Gut (Gut) Vol. 27 Issue 6 Pg. 695-7 (Jun 1986) ISSN: 0017-5749 [Print] England
• PMID: 3721293 (Publication Type: Case Reports, Journal Article)

Chemical References

• Dietary Fats
• Vitamin E
• alpha-tocopherol quinol
• alpha-Tocopherol

Topics

• Adult
• Colitis, Ulcerative (drug therapy)
• Dietary Fats (administration & dosage)
• Dose-Response Relationship, Drug
• Humans
• Male
• Vitamin E (analogs & derivatives, therapeutic use)
• alpha-Tocopherol (analogs & derivatives)