[Action of phytoecdysteroids on the bile-secretory function of the normal liver and in experimental hepatitis].

Abstract

Phytoecdysteroids from Rhaponticum carthemoides (Willd) Iljin and Ajuga turkestanica (Rgl.) Brig in a dose of 5 mg/kg per os markedly stimulate the bile secretion in normal rats treated with single (cyasterone) and 7-day-long (ecdysterone, cyasterone) administration. The chemical composition of the bile is significantly improved because of increased levels of bile acids and bilirubin and a decreased cholesterol content. Phytoecdysteroids (ecdysterone) exert more beneficial effect on the parameters under study in rats with toxic hepatitis induced by heliotrine.

• Authors: V N Syrov, A N Nabiev, M B Sultanov
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1986 May-Jun Vol. 49 Issue 3 Pg. 100-3 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Deĭstvie fitoékdisteroidov na zhelcheotdelitel'nuiu funktsiiu pecheni v norme i pri éksperimental'nom gepatite.
• PMID: 3720929 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Pyrrolizidine Alkaloids
• cyasterone
• Ecdysterone
• Stigmasterol
• heliotrine

Topics

• Animals
• Bile (analysis, drug effects, metabolism)
• Chemical Phenomena
• Chemical and Drug Induced Liver Injury (drug therapy, physiopathology)
• Chemistry
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Ecdysterone (pharmacology, therapeutic use)
• Liver (drug effects, metabolism)
• Male
• Plants, Medicinal
• Pyrrolizidine Alkaloids (toxicity)
• Rats
• Stigmasterol (analogs & derivatives, pharmacology, therapeutic use)
• Time Factors