Effects of the enantiomers of the dihydropyridine derivative 202-791 on contractility, coronary flow and ischemia-related arrhythmias in rat heart.

Abstract

The (+)-enantiomer of the dihydropyridine 202-791 produced coronary constrictor and positive inotropic effects in Langendorff-perfused rat hearts whereas (--)-202-791 showed coronary dilator and negative inotropic effects. Both enantiomers showed the vascular effects at lower concentrations than the myocardial effects. Furthermore, the (+)-enantiomer significantly increased whilst the (--)-enantiomer reduced the number of ventricular ectopic beats occurring during coronary ligation. Arrhythmia-enhancing effects must therefore be considered when the potential therapeutic uses of calcium channel activators are discussed.

• Authors: T Uematsu, N S Cook, R P Hof, S Vozeh, F Follath
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 123 Issue 3 Pg. 455-8 (Apr 29 1986) ISSN: 0014-2999 [Print] Netherlands
• PMID: 3720830 (Publication Type: Journal Article)

Topics

• Animals
• Arrhythmias, Cardiac (etiology, physiopathology)
• Coronary Circulation (drug effects)
• Coronary Disease (complications, physiopathology)
• Male
• Myocardial Contraction (drug effects)
• Rats
• Rats, Inbred Strains
• Stereoisomerism