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Experimental efficacy of apalcillin and cefpiramide compared with that of six other antipseudomonal agents in Pseudomonas aeruginosa burn infections.

Abstract
The therapeutic efficacy of cefpiramide and apalcillin was evaluated and compared with that of six other antipseudomonal beta-lactam antibiotics in an experimental mouse burn infection due to Pseudomonas aeruginosa. Both cefpiramide and apalcillin were as potent as cefsulodin and more potent than carbenicillin, cefotaxime, cefoperazone, piperacillin and gentamicin in protecting the infected mice from fatal bacteraemia and in eradicating Ps. aeruginosa from the infected site.
AuthorsK P Fu, T Vince, P P Hung, J F Gregory
JournalDrugs under experimental and clinical research (Drugs Exp Clin Res) Vol. 12 Issue 4 Pg. 303-6 ( 1986) ISSN: 0378-6501 [Print] Switzerland
PMID3720518 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Cephalosporins
  • Naphthyridines
  • apalcillin
  • Ampicillin
  • cefpiramide
Topics
  • Ampicillin (analogs & derivatives, therapeutic use)
  • Animals
  • Anti-Bacterial Agents (therapeutic use)
  • Burns (complications)
  • Cephalosporins (therapeutic use)
  • Female
  • Mice
  • Naphthyridines
  • Pseudomonas Infections (drug therapy)
  • Wound Infection (drug therapy)

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