Abstract | OBJECTIVE: Our current study tried to assay the role of long noncoding RNAs (lncRNAs) TLR8-AS1 in regulating preeclampsia. METHODS: RESULTS: High expression of TLR8-AS1 was detected in placental tissues of preeclampsia patients and LPS-induced trophoblast cells. In addition, overexpression of TLR8-AS1 arrested the proliferation, migration and invasion of trophoblast cells, which was related to the upregulation of TLR8 expression. Mechanistically, TLR8-AS1 recruited STAT1 to bind to the TLR8 promoter region, and thus promoted the transcription of TLR8. Meanwhile, overexpression of TLR8-AS1 was shown to aggravate preeclampsia by elevating TLR8 in vivo . CONCLUSION: Our study confirmed that TLR8-AS1 aggravated the progression of preeclampsia through increasing the expression of STAT1 and TLR8.
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Authors | Chuyu Peng, Jianbin Zhu, Hong Guo, Ling Zhao, Feifei Wu, Bo Liu |
Journal | Journal of hypertension
(J Hypertens)
Vol. 41
Issue 8
Pg. 1245-1257
(08 01 2023)
ISSN: 1473-5598 [Electronic] Netherlands |
PMID | 37199563
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. |
Chemical References |
- Lipopolysaccharides
- MicroRNAs
- RNA, Long Noncoding
- STAT1 protein, human
- STAT1 Transcription Factor
- TLR8 protein, human
- Toll-Like Receptor 8
- Stat1 protein, rat
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Topics |
- Animals
- Female
- Humans
- Pregnancy
- Rats
- Cell Line, Tumor
- Cell Movement
(genetics)
- Cell Proliferation
- Lipopolysaccharides
(metabolism)
- MicroRNAs
(genetics)
- Placenta
(metabolism)
- Pre-Eclampsia
(genetics, metabolism)
- RNA, Long Noncoding
(genetics, metabolism)
- STAT1 Transcription Factor
(genetics, metabolism)
- Toll-Like Receptor 8
(genetics, metabolism)
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