Indeloxazine hydrochloride (
Indeloxazine) has been known as a new type
drug with enhancing effects on memory and learning processes in various experimental models. In the present studies, effects of
Indeloxazine on brain energy and
glucose metabolisms were determined in four-vessel occlusion rat model. Since a critical point of ischemic time for the recovery of brain energy levels existed between 30 min and 60 min in this model, effects of
Indeloxazine were determined in the rat model of 60 min recirculation following 60 min
ischemia. One-week dosing of
Indeloxazine at 2 mg/kg showed slight increases in
ATP and total
adenine nucleotides levels. To elucidate the mechanism of improving action of
Indeloxazine on brain energy levels, effects on
glucose metabolism were determined. Non-treated group of 60 min ischemia-60 min recirculation showed severe reduction of 14C-2-deoxyglucose metabolism in comparison to normal control group.
Indeloxazine-treated group showed a slight improvement of 14C-2-deoxyglucose metabolism in comparison to non-treated group. Furthermore, high 14C-2-deoxyglucose metabolism was observed in parts of hippocampus, cortex and thalamus. From these results, it seems possible that
Indeloxazine has some protective effects on brain damage in four-vessel occlusion rat model.