Pediatric combined living donor liver and kidney transplantation for primary hyperoxaluria type 2.

Abstract

We report the case of a 12-year-old boy with primary hyperoxaluria type 2 (PH2) presenting with end-stage renal disease and systemic oxalosis who underwent a combined living donor liver and kidney transplant from 3 donors, 1 of whom was a heterozygous carrier of the mutation. Plasma oxalate and creatinine levels normalized immediately following the transplant and remain normal after 18 months. We recommend combined liver and kidney transplantation as the preferred therapeutic option for children with primary hyperoxaluria type 2 with early-onset end-stage renal disease.

• Authors: Somashekara Hosaagrahara Ramakrishna, Akhila Hassan, Mohan Babu Kasala, Karnan Perumal, Chaitra Venkategowda, Selvakumar Malleeswaran, Muthukumar Periasamy, Muruganandham Kaliyaperumal, Rajanikanth V Patcha, Joy Varghese, Mettu Srinivas Reddy
• Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (Am J Transplant) Vol. 23 Issue 10 Pg. 1622-1625 (10 2023) ISSN: 1600-6143 [Electronic] United States
• PMID: 37187295 (Publication Type: Case Reports)
• Copyright: Copyright © 2023 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved.

Topics

• Male
• Child
• Humans
• Kidney Transplantation
• Liver Transplantation
• Living Donors
• Hyperoxaluria, Primary (genetics, surgery)
• Hyperoxaluria
• Kidney Failure, Chronic (surgery)
• Liver