[Evaluation of the in vitro activity of flumequine on bacterial strains recently isolated in the hospital].

Abstract

The in vitro activity of the quinolone derivative flumequine against 1918 bacterial strains, isolated from urinary tract infections, has been compared to the antibacterial activity of other compounds, such as pipemidic acid, oxolinic acid and cefazolin. The results are reported in terms of minimal inhibitory concentrations (MICs) and geometrical mean (MG) of MICs. Flumequine appeared to be the most effective molecule over all the clinical isolates, showing a MG of MICs of 1.12 and a MIC 90 of 32 micrograms/ml.

• Authors: E Nani, G Amato, D Anzivino, I Covelli
• Journal: Bollettino dell'Istituto sieroterapico milanese (Boll Ist Sieroter Milan) Vol. 65 Issue 1 Pg. 14-21 ( 1986) ISSN: 0021-2547 [Print] Italy
• Vernacular Title: Valutazione dell'attività in vitro della flumechina su ceppi batterici di recente isolamento ospedaliero.
• PMID: 3718678 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fluoroquinolones
• Quinolizines
• Cefazolin
• Oxolinic Acid
• Pipemidic Acid
• flumequine

Topics

• Bacteria (drug effects)
• Cefazolin (pharmacology)
• Fluoroquinolones
• Humans
• In Vitro Techniques
• Microbial Sensitivity Tests
• Oxolinic Acid (pharmacology)
• Pipemidic Acid (pharmacology)
• Quinolizines (pharmacology)
• Structure-Activity Relationship
• Urinary Tract Infections (microbiology)