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Development of pulmonary aneurysm in primary pulmonary hypertension: a case report.

Abstract
Selected cases of severe primary pulmonary arterial hypertension and associated pulmonary vascular disease have been related to the oral ingestion of aminorex fumarate, an anorexigen obviously responsible for an epidemic of primary pulmonary hypertension in Western Europe between 1967 and 1970. This report describes a fifteen year follow-up of a female patient with aminorex fumarate related pulmonary hypertension and the uncommon finding of the formation of an excessive fusiform pulmonary trunk aneurysm in the late stage of the disease process. The progressive clinical course was followed by serial chest x-ray films and repeat right heart catheterization. The diagnosis of a main stem pulmonary artery aneurysm was noninvasively established by two-dimensional echocardiography and confirmed by contrast-enhanced computed tomography and radionuclide blood pool imaging. The patient is alive, thus no histologic correlate of this entity is available at present.
AuthorsC A Nienaber, R P Spielmann, R Montz, W Bleifeld, D G Mathey
JournalAngiology (Angiology) Vol. 37 Issue 4 Pg. 319-24 (Apr 1986) ISSN: 0003-3197 [Print] United States
PMID3717697 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Appetite Depressants
  • Oxazoles
  • Aminorex
  • aminorex fumarate
Topics
  • Aminorex (adverse effects, analogs & derivatives)
  • Aneurysm (diagnosis, etiology)
  • Appetite Depressants (adverse effects)
  • Cardiac Catheterization
  • Echocardiography
  • Female
  • Follow-Up Studies
  • Heart (diagnostic imaging)
  • Humans
  • Hypertension, Pulmonary (chemically induced, complications)
  • Lung (diagnostic imaging)
  • Middle Aged
  • Oxazoles (adverse effects)
  • Pulmonary Artery
  • Radionuclide Imaging
  • Time Factors
  • Tomography, X-Ray Computed

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