Abstract |
Acute renal failure is a serious complication of reconstructive aortoiliac surgery. The question was raised whether its etiology includes interaction between preoperative angiographic contrast medium and intra-operative clamping of the renal arteries. Renal arteries of 180 rats were bilaterally clamped 10 to 120 min and serum urea was determined from 3 h to 7 days later. In 35 rats 40 min clamping alone produced an increase in urea reaching a maximum 1 day later (median increase 70%). In 3 groups of 12 rats intravenous injection of the contrast medium metrizoate alone in doses 1, 2 and 3 g I/kg body-weight produced no significant increase in urea. Intravenous injection of the same doses to 3 groups of 10 rats each followed 1 h later by renal arterial occlusion for 40 min produced median urea increases one day later of 110, 130 and 170 per cent, respectively, in the 3 groups. The increase was higher than that produced by contrast medium alone (p less than 0.01) or by renal artery clamping alone (p less than 0.05) indicating a potentiation of transient renal failure by the combination of contrast medium and renal arterial clamping.
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Authors | C Cederholm, T Almén, D Bergqvist, K Golman, R Takolander |
Journal | Acta radiologica: diagnosis
(Acta Radiol Diagn (Stockh))
1986 Mar-Apr
Vol. 27
Issue 2
Pg. 241-7
ISSN: 0567-8056 [Print] Sweden |
PMID | 3716872
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Iodobenzoates
- Metrizoic Acid
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Topics |
- Acute Kidney Injury
(chemically induced, etiology)
- Animals
- Blood Urea Nitrogen
- Iodobenzoates
(adverse effects)
- Male
- Metrizoic Acid
(adverse effects)
- Postoperative Complications
(etiology)
- Rats
- Rats, Inbred Strains
- Renal Artery Obstruction
(blood, complications)
- Time Factors
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