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[A unique psychopharmacologic profile of adrafinil in mice].

Abstract
The following psychopharmacological effects of adrafinil have been observed in mice: increase in locomotor activity (64-256 mg.kg-1), antagonism (16-128 mg.kg-1) of the hypnotic effects of barbitone but not of pentobarbitone, reduction of immobility duration in the forced swimming test (16-256 mg.kg-1); slight antagonism (256 mg.kg-1) of electroshock-induced convulsions; no modification of rectal temperature; no stereotyped or climbing behaviour; no increase in lethality in aggregated mice (LD50 isolated = 1022 mg.kg-1, LD50 aggregated = 859 mg.kg-1); lack of effects on the provisional tests for antidepressants: no interaction with reserpine-, oxotremorine-, or apomorphine-induced hypothermia but potentiation of yohimbine-induced toxicity; lack of peripheral sympathetic effects (no mydriasis, no salivation, no contraction of the pilomotor muscles, no antagonism of reserpine-induced ptosis); lack of peripheral anticholinergic effects (no mydriasis, no antagonism of oxotremorine-induced salivation or lacrimation). As compared to no analeptic, anticholinergic or antidepressant drugs, adrafinil shows a unique behavioural profile in mice defined on the one hand by a specific stimulant activity associated with antidepressant-like effects that do no seem related to a beta-adrenergic mechanism and on the other hand by a lack of dopaminergic effects. Most adrafinil-induced effects (increase in locomotor activity, reduction of immobility duration in the forced swimming test) may correspond to a central alpha 1-adrenergic stimulation, but the unexpected lack of peripheral sympathetic effects remains unexplained.
AuthorsF A Rambert, J Pessonnier, J E de Sereville, A M Pointeau, J Duteil
JournalJournal de pharmacologie (J Pharmacol) 1986 Jan-Mar Vol. 17 Issue 1 Pg. 37-52 ISSN: 0021-793X [Print] France
Vernacular TitleProfil psychopharmacologique original de l'adrafinil chez la souris.
PMID3713198 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Barbiturates
  • Hydroxamic Acids
  • Yohimbine
  • Oxotremorine
  • Reserpine
  • adrafinil
  • Apomorphine
Topics
  • Animals
  • Apomorphine (pharmacology)
  • Barbiturates (pharmacology)
  • Behavior, Animal (drug effects)
  • Body Temperature (drug effects)
  • Drug Interactions
  • Electroshock
  • Hydroxamic Acids (metabolism, pharmacology, toxicity)
  • Male
  • Mice
  • Motor Activity (drug effects)
  • Oxotremorine (pharmacology)
  • Pupil (drug effects)
  • Reserpine (pharmacology)
  • Sleep (drug effects)
  • Stereotyped Behavior (drug effects)
  • Yohimbine (pharmacology)

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