Abstract |
The following psychopharmacological effects of adrafinil have been observed in mice: increase in locomotor activity (64-256 mg.kg-1), antagonism (16-128 mg.kg-1) of the hypnotic effects of barbitone but not of pentobarbitone, reduction of immobility duration in the forced swimming test (16-256 mg.kg-1); slight antagonism (256 mg.kg-1) of electroshock-induced convulsions; no modification of rectal temperature; no stereotyped or climbing behaviour; no increase in lethality in aggregated mice (LD50 isolated = 1022 mg.kg-1, LD50 aggregated = 859 mg.kg-1); lack of effects on the provisional tests for antidepressants: no interaction with reserpine-, oxotremorine-, or apomorphine- induced hypothermia but potentiation of yohimbine-induced toxicity; lack of peripheral sympathetic effects (no mydriasis, no salivation, no contraction of the pilomotor muscles, no antagonism of reserpine-induced ptosis); lack of peripheral anticholinergic effects (no mydriasis, no antagonism of oxotremorine-induced salivation or lacrimation). As compared to no analeptic, anticholinergic or antidepressant drugs, adrafinil shows a unique behavioural profile in mice defined on the one hand by a specific stimulant activity associated with antidepressant-like effects that do no seem related to a beta- adrenergic mechanism and on the other hand by a lack of dopaminergic effects. Most adrafinil-induced effects (increase in locomotor activity, reduction of immobility duration in the forced swimming test) may correspond to a central alpha 1-adrenergic stimulation, but the unexpected lack of peripheral sympathetic effects remains unexplained.
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Authors | F A Rambert, J Pessonnier, J E de Sereville, A M Pointeau, J Duteil |
Journal | Journal de pharmacologie
(J Pharmacol)
1986 Jan-Mar
Vol. 17
Issue 1
Pg. 37-52
ISSN: 0021-793X [Print] France |
Vernacular Title | Profil psychopharmacologique original de l'adrafinil chez la souris. |
PMID | 3713198
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Barbiturates
- Hydroxamic Acids
- Yohimbine
- Oxotremorine
- Reserpine
- adrafinil
- Apomorphine
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Topics |
- Animals
- Apomorphine
(pharmacology)
- Barbiturates
(pharmacology)
- Behavior, Animal
(drug effects)
- Body Temperature
(drug effects)
- Drug Interactions
- Electroshock
- Hydroxamic Acids
(metabolism, pharmacology, toxicity)
- Male
- Mice
- Motor Activity
(drug effects)
- Oxotremorine
(pharmacology)
- Pupil
(drug effects)
- Reserpine
(pharmacology)
- Sleep
(drug effects)
- Stereotyped Behavior
(drug effects)
- Yohimbine
(pharmacology)
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