[Correlation between the anti-arrhythmia effect of ethacizin and pharmacokinetic parameters in a model of rhythm adoption by the heart].

Abstract

Pharmacokinetics and pharmacodynamics of ethacizin were studied in a model of rhythm adoption by the heart, with the drug administered intravenously to anesthetized cats. A relation was demonstrated between blood ethacizin pattern and the drug's biphasic effect on the adoption of stimulation-imposed pace by the heart and ventricular fibrillation threshold. The estimated correlation coefficients, reflecting the relationship between the development of ethacizin anti-arrhythmic and antifibrillation effects and variation of its plasma levels between 10 and 120 min after the administration, were rather high (-0.85 and +0.93, respectively). Ethacizin shows anti-arrhythmic and antifibrillation activity when its plasma levels are between 2400 and 200 ng/ml.

• Authors: A P Rodionov, S Iu Berdiaev, N V Shestakova, N V Darinskiĭ, N V Kaverina
• Journal: Kardiologiia (Kardiologiia) Vol. 26 Issue 4 Pg. 45-8 (Apr 1986) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Korreliatsiia mezhdu antiaritmicheskim deĭstviem etatsizina i farmakokineticheskimi parametrami na modeli usvoeniia ritma serdtsa.
• PMID: 3712951 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Phenothiazines
• diethylamino-ethmozine
• Moricizine

Topics

• Animals
• Anti-Arrhythmia Agents (therapeutic use)
• Arrhythmias, Cardiac (drug therapy)
• Biological Availability
• Cats
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Half-Life
• Kinetics
• Moricizine (analogs & derivatives)
• Phenothiazines (metabolism, therapeutic use)
• Time Factors