[Studies on antimicrobial concentration of clindamycin phosphate in serum, pelvic dead space exudate, and pelvic organs/tissues].

Abstract

In women undergoing radical and total abdominal hysterectomy, clindamycin phosphate (CLDM-P) in a dose of 1,200 mg was administered by intravenous drip infusion over 1 hour and the drug concentrations in serum and pelvic dead space exudate, as well as pelvic organs/tissues, were determined over time. The following results were obtained: The serum concentration of clindamycin (CLDM) after intravenous infusion showed the peak value of 24.54 +/- 7.02 micrograms/ml at the end of infusion and then gradually decreased to 3.87 +/- 0.70 micrograms/ml in 6 hours. Concentration in pelvic dead space exudate, which was 2.82 +/- 3.90 micrograms/ml at the end of intravenous infusion, gradually increased to the peak value of 13.49 +/- 6.62 micrograms/ml in 1 hour. Two hours after infusion, the level of 12.43 +/- 5.56 micrograms/ml outstripped serum concentration. Continuously in excess of serum concentration, the exudate concentration gradually decreased to 6.65 +/- 2.27 micrograms/ml at 6 hours after infusion. Cubital venous serum concentration (16.36 +/- 3.68 micrograms/ml) was almost equal to uterine arterial serum concentration (16.36 +/- 4.05 micrograms/ml) of CLDM at uterine removal. In the pelvic organ/tissue concentrations, 15.71 +/- 3.86 micrograms/g in endometrium was highest, followed by 15.19 +/- 3.80 micrograms/g in oviduct, 14.80 +/- 3.52 micrograms/g in myometrium, 14.74 +/- 4.02 micrograms/g in ovary, 14.09 +/- 2.90 micrograms/g in portio vaginalis. The concentration was lowest (11.49 +/- 1.44 micrograms/g) in cervix uteri. Clinically, combined treatment with CLDM-P and ceftizoxime was excellently effective for endometritis induced by P. asaccharolyticus.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: T Obata, J Sasaki, K Takahashi, M Eguchi, Y Yamamoto, K Deguchi, S Fukayama, Y Nishimura
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 39 Issue 2 Pg. 317-25 (Feb 1986) ISSN: 0368-2781 [Print] Japan
• PMID: 3712747 (Publication Type: English Abstract, Journal Article)

Chemical References

• Clindamycin
• clindamycin phosphate

Topics

• Adult
• Aged
• Clindamycin (administration & dosage, analogs & derivatives, metabolism, therapeutic use)
• Endometritis (drug therapy)
• Exudates and Transudates (metabolism)
• Female
• Humans
• Infusions, Parenteral
• Middle Aged
• Models, Biological
• Pelvis (metabolism)
• Uterus (metabolism)