An Evaluation of Platelet Factor 4, Beta-Thromboglobulin and Mean Platelet Volume in the Assessment of Thrombotic Risks in Subjects with Diabetes Mellitus at Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria.

Abstract

BACKGROUND:

Beta-thromboglobulin and platelet factor 4 are known platelet-specific proteins that are stored in the platelet alpha-granules and released during platelet activation. The measurement of these proteins can reflect the degree of platelet activation and indirectly suggest a pro-thrombotic state. This study aimed at determining serum levels of Betathromboglobulin, mean platelet volume, and platelet factor 4 in diabetes mellitus and control subjects in Lagos, Nigeria.

MATERIALS AND METHODS:

Using enzyme-linked immunosorbent assay at Lagos State University Teaching Hospital, Ikeja, this study evaluated serum concentrations of Beta-thromboglobulin, and platelet factor 4, the mean platelet volume was also determined from a Full Blood Count of all participants. Data were analyzed using Statistical Package for Social Sciences, Inc., Chicago, Ill; version 26.0. The continuous variables were given as mean ± standard deviation. The P-value was considered to be statistically significant when ≤0.05.

RESULTS:

Beta-thromboglobulin concentration was higher and statistically significant (7.82 ± 1.54ng/ml and 6.70 ± 2.23 ng/ml; P = 0.01), platelet factor 4 (39.86 ± 11.25 ng/ml and 47.73 ± 21.73ng/ml, P = 0.06) and mean platelet volume (10.26± 1.06fl and 10.29 ± 1.02fl P = 0.89) were not statistically significant in the diabetes mellitus group compared with non-diabetic participants, platelet factor 4 was higher in the older than younger diabetes mellitus participants.

CONCLUSION:

Elevated Beta-thromboglobulin may suggest a possible increase in thrombotic risks among diabetes mellitus.

• Authors: A O Dada, O A Dada, A A Akinbami, A R Bamiro, I E Uche, O I Adeyemi, O A Kareem, O B Okunowo, M R Dosu
• Journal: West African journal of medicine (West Afr J Med) Vol. 40 Issue 4 Pg. 357-361 (04 28 2023) ISSN: 0189-160X [Print] Nigeria
• PMID: 37115730 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 by West African Journal of Medicine.

Chemical References

• Platelet Factor 4
• beta-Thromboglobulin

Topics

• Humans
• Platelet Factor 4
• beta-Thromboglobulin (metabolism)
• Mean Platelet Volume
• Nigeria (epidemiology)
• Universities
• Diabetes Mellitus (epidemiology)
• Hospitals, Teaching