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Large keratoacanthomas in difficult locations treated with intralesional 5-fluorouracil.

Abstract
Keratoacanthoma is a benign tumor; however, it may cause massive destruction of normal tissue during its rapid growth phase. Intralesional 5-fluorouracil (5-FU) has been shown to be an effective treatment for keratoacanthoma. We have successfully treated five patients with large keratoacanthomas in difficult locations. There have been no recurrences during follow-up periods ranging from 18 to 45 months. Intralesional 5-FU may be ineffective for keratoacanthomas that are not rapidly proliferating.
AuthorsC M Parker, C W Hanke
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 14 Issue 5 Pt 1 Pg. 770-7 (May 1986) ISSN: 0190-9622 [Print] United States
PMID3711381 (Publication Type: Journal Article)
Chemical References
  • Fluorouracil
Topics
  • Adult
  • Aged
  • Facial Dermatoses (drug therapy)
  • Fluorouracil (administration & dosage, therapeutic use)
  • Follow-Up Studies
  • Humans
  • Injections
  • Keratoacanthoma (drug therapy)
  • Male
  • Middle Aged
  • Time Factors

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