| Abstract | Abdominopelvic irradiation was given to 18 stage II-IV ovarian carcinoma patients who completed cisplatinum-based combination chemotherapy, were in complete clinical remission, and who underwent second-look laparotomy. The survival as well as the progression-free interval (PFI) was significantly longer in patients with a negative second-look laparotomy than in those with limited residual disease at this operation. Abdominopelvic irradiation was not effective in patients with limited residual disease at second-look laparotomy (3 year survival--34.3% and median PFI from second-look laparotomy--4.8 months). Even in patients with a negative second-look laparotomy the median PFI was only 13 months from this operation and the 3-year survival was 87.5%. The results were similar to other comparable series in which no treatment was administered to patients with a negative second-look laparotomy. |
| Authors | J Menczer, M Modan, J Brenner, G Ben-Baruch, H Brenner |
| Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 24
Issue 2
Pg. 149-54
(Jun 1986)
ISSN: 0090-8258 UNITED STATES |
| PMID | 3710262
(Publication Type: Comparative Study, Journal Article)
|
| Chemical References |
- Cisplatin
- Doxorubicin
- Cyclophosphamide
|
| Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Cisplatin
(administration & dosage)
- Combined Modality Therapy
- Cyclophosphamide
(administration & dosage)
- Doxorubicin
(administration & dosage)
- Female
- Humans
- Laparotomy
- Middle Aged
- Ovarian Neoplasms
(drug therapy, mortality, radiotherapy)
- Postoperative Care
- Probability
- Reoperation
- Time Factors
|
