Tubular antigen-associated renal disease in New Zealand white rabbits.

Abstract

Rabbits immunized with autologous renal tubular antigen (Fx1A) developed tubulointerstitial nephritis whereas sheep anti-Fx1A antibody administered i.v. produced glomerulonephritis (GN). This lesion showed heavy granular glomerular deposition of immunoglobulin and subepithelial electron dense deposits, early proteinuria, leucocyte independence and a temporal pattern of quantitated glomerular antibody binding distinct from that reported to occur in passive Heymann's nephritis in rats. Isoelectric focusing followed by immunoblotting of deoxycholate-soluble Fx1A antigens with the heterologous and autologous antibodies, indicated species differences in epitope recognition which could account for dissociation between the two models.

• Authors: M J Nicol, J H Miller, T J Neale
• Journal: Clinical and experimental immunology (Clin Exp Immunol) Vol. 63 Issue 3 Pg. 629-38 (Mar 1986) ISSN: 0009-9104 [Print] England
• PMID: 3708904 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens
• renal tubular antigen

Topics

• Animals
• Antigens (immunology)
• Disease Models, Animal
• Glomerulonephritis (immunology, pathology)
• Kidney Glomerulus (ultrastructure)
• Kidney Tubules (ultrastructure)
• Microscopy, Electron
• Nephritis, Interstitial (immunology, pathology)
• Rabbits
• Sheep
• Species Specificity