[Effect of blastolysin on the development of specific immunity to whooping cough].

Abstract

The influence of blastolysin, the cell-wall glycopeptide of Lactobacillus bulgaricus, on the main immunobiological properties of pertussis vaccine, its immunogenicity and toxicity, has been studied. The use of blastolysin, introduced as a stimulating agent in definite doses and following definite administration schedules, has been shown to permit achieving not only an increase in the immunogenicity of the corpuscular pertussis vaccine, but also a considerable decrease in its toxicity and histamine-sensitizing activity.

• Authors: I B Shepeleva, N S Zakharova, T N Remova, I G Bazhanova, M V Britsina
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) Issue 1 Pg. 62-5 (Jan 1986) ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Vliianie blastolizina na razvitie spetsificheskogo immuniteta k kokliushu.
• PMID: 3705806 (Publication Type: English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Anti-Bacterial Agents
• Glycopeptides
• Pertussis Vaccine
• blastolysin
• Histamine

Topics

• Adjuvants, Immunologic (therapeutic use)
• Animals
• Anti-Bacterial Agents
• Dose-Response Relationship, Drug
• Dose-Response Relationship, Immunologic
• Drug Evaluation, Preclinical
• Drug Interactions
• Glycopeptides (therapeutic use)
• Histamine (immunology)
• Immunity (drug effects)
• Immunization
• Mice
• Mice, Inbred C57BL
• Mice, Inbred CBA
• Pertussis Vaccine (immunology, toxicity)
• Whooping Cough (immunology, prevention & control)