Abstract |
Knowing the in vivo inhibitory effect of the beta-adrenoreceptor antagonists on gastric mucosa carbonic anhydrase and the high clinical efficacy of " Ulcosilvanil" in the healing of gastric and duodenal ulcers, the authors combined propranolol with smaller doses of " Ulcosilvanil" in 925 active duodenal ulcer patients, divided into four groups. The first 236 patients were treated with small doses of " Ulcosilvanil" (20 mg/kg b.w./day active substance), the second group (of 258 cases) with high doses (35 mg/kg b.w./day) of " Ulcosilvanil", the third one (182 subjects) with propranolol only (60 mg/day) and the fourth group (349 patients) with small doses of " Ulcosilvanil" associated with 60 mg/day propranolol. Pain disappeared in all the cases of groups 1,2 and 4 after 3-6 days of treatment and in 40% of the third group. Basal acid output decreased, after 10 days of treatment, from 6.15 +/- 1.57 to 1.94 +/- 0.66 mEq/h in the first group (p less than 0.001), from 7.98 +/- 2.34 to 0.01 +/- 0.01 mEq/h in the second group (p less than 0.001), from 6.43 +/- 2.45 to 2.09 +/- 0.50 mEq/h in the third group (p less than 0.02) and from 6.76 +/- 2.80 to 0.011 +/- 0.01 mEq/h in the fourth group (p less than 0.001). Endoscopic healing was achieved, after 14 days of treatment, respectively in 78.5%, 92.4%, 51.6% and 88.41%; this percentages increased to 82.3%, 96.8%, 68.1% and 93.5% after 21 day of treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
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Authors | I Puşcaş, A Reznicek, G Búzás, D Milaş, E Kovács, D Sturzu, F Perşa, R Nemeş-Brateş, S Vălean |
Journal | Medecine interne
(Med Interne)
1986 Jan-Mar
Vol. 24
Issue 1
Pg. 75-9
ISSN: 0377-1202 [Print] Romania |
PMID | 3704506
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anti-Ulcer Agents
- Bicarbonates
- Carbonic Anhydrase Inhibitors
- Drug Combinations
- Ulcosilvanil
- Propranolol
- Acetazolamide
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Topics |
- Acetazolamide
- Anti-Ulcer Agents
(administration & dosage)
- Bicarbonates
- Carbonic Anhydrase Inhibitors
(administration & dosage)
- Dose-Response Relationship, Drug
- Drug Combinations
- Drug Therapy, Combination
- Duodenal Ulcer
(drug therapy)
- Gastric Acid
(metabolism)
- Humans
- Propranolol
(administration & dosage)
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